diff --git a/modules/gdscript/tests/scripts/runtime/features/self_destruction.gd b/modules/gdscript/tests/scripts/runtime/features/self_destruction.gd
new file mode 100644
index 00000000000..442335faeba
--- /dev/null
+++ b/modules/gdscript/tests/scripts/runtime/features/self_destruction.gd
@@ -0,0 +1,50 @@
+# https://github.com/godotengine/godot/issues/75658
+
+class MyObj:
+	var callable: Callable
+
+	func run():
+		callable.call()
+
+	var prop:
+		set(value):
+			callable.call()
+		get:
+			callable.call()
+			return 0
+
+	func _on_some_signal():
+		callable.call()
+
+	func _init(p_callable: Callable):
+		self.callable = p_callable
+
+signal some_signal
+
+var obj: MyObj
+
+func test():
+	# Call.
+	obj = MyObj.new(nullify_obj)
+	obj.run()
+	print(obj)
+
+	# Get.
+	obj = MyObj.new(nullify_obj)
+	var _aux = obj.prop
+	print(obj)
+
+	# Set.
+	obj = MyObj.new(nullify_obj)
+	obj.prop = 1
+	print(obj)
+
+	# Signal handling.
+	obj = MyObj.new(nullify_obj)
+	@warning_ignore("return_value_discarded")
+	some_signal.connect(obj._on_some_signal)
+	some_signal.emit()
+	print(obj)
+
+func nullify_obj():
+	obj = null
diff --git a/modules/gdscript/tests/scripts/runtime/features/self_destruction.out b/modules/gdscript/tests/scripts/runtime/features/self_destruction.out
new file mode 100644
index 00000000000..ee4024a524d
--- /dev/null
+++ b/modules/gdscript/tests/scripts/runtime/features/self_destruction.out
@@ -0,0 +1,5 @@
+GDTEST_OK
+<null>
+<null>
+<null>
+<null>
diff --git a/tests/core/object/test_object.h b/tests/core/object/test_object.h
index 57bc65328a0..a84ee8f0ba9 100644
--- a/tests/core/object/test_object.h
+++ b/tests/core/object/test_object.h
@@ -37,6 +37,16 @@
 
 #include "tests/test_macros.h"
 
+#ifdef SANITIZERS_ENABLED
+#ifdef __has_feature
+#if __has_feature(address_sanitizer) || __has_feature(thread_sanitizer)
+#define ASAN_OR_TSAN_ENABLED
+#endif
+#elif defined(__SANITIZE_ADDRESS__) || defined(__SANITIZE_THREAD__)
+#define ASAN_OR_TSAN_ENABLED
+#endif
+#endif
+
 // Declared in global namespace because of GDCLASS macro warning (Windows):
 // "Unqualified friend declaration referring to type outside of the nearest enclosing namespace
 // is a Microsoft extension; add a nested name specifier".
@@ -499,6 +509,74 @@ TEST_CASE("[Object] Notification order") { // GH-52325
 	memdelete(test_notification_object);
 }
 
+TEST_CASE("[Object] Destruction at the end of the call chain is safe") {
+	Object *object = memnew(Object);
+	ObjectID obj_id = object->get_instance_id();
+
+	class _SelfDestroyingScriptInstance : public _MockScriptInstance {
+		Object *self = nullptr;
+
+		// This has to be static because ~Object() also destroys the script instance.
+		static void free_self(Object *p_self) {
+#if defined(ASAN_OR_TSAN_ENABLED)
+			// Regular deletion is enough becausa asan/tsan will catch a potential heap-after-use.
+			memdelete(p_self);
+#else
+			// Without asan/tsan, try at least to force a crash by replacing the otherwise seemingly good data with garbage.
+			// Operations such as dereferencing pointers or decreasing a refcount would fail.
+			// Unfortunately, we may not poison the memory after the deletion, because the memory would no longer belong to us
+			// and on doing so we may cause a more generalized crash on some platforms (allocator implementations).
+			p_self->~Object();
+			memset((void *)p_self, 0, sizeof(Object));
+			Memory::free_static(p_self, false);
+#endif
+		}
+
+	public:
+		Variant callp(const StringName &p_method, const Variant **p_args, int p_argcount, Callable::CallError &r_error) override {
+			free_self(self);
+			return Variant();
+		}
+		Variant call_const(const StringName &p_method, const Variant **p_args, int p_argcount, Callable::CallError &r_error) override {
+			free_self(self);
+			return Variant();
+		}
+		bool has_method(const StringName &p_method) const override {
+			return p_method == "some_method";
+		}
+
+	public:
+		_SelfDestroyingScriptInstance(Object *p_self) :
+				self(p_self) {}
+	};
+
+	_SelfDestroyingScriptInstance *script_instance = memnew(_SelfDestroyingScriptInstance(object));
+	object->set_script_instance(script_instance);
+
+	SUBCASE("Within callp()") {
+		SUBCASE("Through call()") {
+			object->call("some_method");
+		}
+		SUBCASE("Through callv()") {
+			object->callv("some_method", Array());
+		}
+	}
+	SUBCASE("Within call_const()") {
+		Callable::CallError call_error;
+		object->call_const("some_method", nullptr, 0, call_error);
+	}
+	SUBCASE("Within signal handling (from emit_signalp(), through emit_signal())") {
+		Object emitter;
+		emitter.add_user_signal(MethodInfo("some_signal"));
+		emitter.connect("some_signal", Callable(object, "some_method"));
+		emitter.emit_signal("some_signal");
+	}
+
+	CHECK_MESSAGE(
+			ObjectDB::get_instance(obj_id) == nullptr,
+			"Object was tail-deleted without crashes.");
+}
+
 } // namespace TestObject
 
 #endif // TEST_OBJECT_H