diff --git a/main/main.cpp b/main/main.cpp
index b08fa12f9f1..27fd0420ab8 100644
--- a/main/main.cpp
+++ b/main/main.cpp
@@ -286,6 +286,14 @@ Error Main::setup(const char *execpath, int argc, char *argv[], bool p_second_ph
 #endif
 
 	while (I) {
+#ifdef OSX_ENABLED
+		// Ignore the process serial number argument passed by macOS Gatekeeper.
+		// Otherwise, Godot would try to open a non-existent project on the first start and abort.
+		if (I->get().begins_with("-psn_")) {
+			I = I->next();
+			continue;
+		}
+#endif
 
 		List<String>::Element *N = I->next();